Programmable materials based on polymers of defined monomer sequence PolyMat

Inspired by natural macromolecules, sequence‐defined synthetic polymers are promising materials building blocks that integrate the sequence‐derived activity of natural biopolymers with the robustness and versatility of synthetic systems. Sequence-defined macromolecules are components of natural matter, that creates living objects able to move, work and even think. In spite of many efforts, man-made materials are still far away from functions that are displayed by natural matter. To reach for the diverse structures and complex properties achieved by native biological polymers sequence programmability of the synthetic polymer is required.

Recently, we have developed a new synthesis method for sequence-defined polymers, based on system chemistry approaches. The method has many advantages over existing methods such as scalability, low cost, reduced amount of solvents, easy protocol. This innovative solution has opened the door to large-scale synthesis of polymers with a specific sequence and enabled their use as building blocks in materials. In this project based on our invention we are going to develop new polymer materials built form sequence-defined polymers with finely tunable properties. The properties of the materials are programmed by monomer sequence.

Polymers as a next generation data storage media PolyDigit

The nature uses DNA for data storage – natural polymers made of nucleotides that contain all the information necessary for the proliferation of living organisms. Defined Sequence Polymers (SDPs) offer a stable, resource-efficient, energy-efficient, and sustainable data storage solution. The properties of synthetic polymers can be precisely modulated and adapted to the requirements. The characteristics of the polymer can be fine-tuned by selecting appropriate building blocks from a wide library of synthetic monomers. Modern, advanced nanosynthesis methods allow materials to be easily produced with the precision of monolayers. Macromolecules can be sequentially arranged in a small volume and used as high-capacity data storage materials. Currently, the challenge is to read the information stored in digital polymers easily and quickly. The lack of convenient methods for reading information using non-destructive techniques prevents the development of new data storage materials based on synthetic polymers. The project aims to study fluorescent polymer materials for their usefulness for storing data and reading information encoded in the monomer sequence based on the fluorescence pattern.

The project aims to develop a new class of fluorescent polymers as a new generation of data carriers.


Project No 2021/42/E/ST4/00010 funded by Polish National Science Centre

Nature-inspired polymer sensors for improved drinking water quality control PolyProbe

The latest achievements in the field of organic and polymer chemistry, have made possible the synthesis of abiological polymers with a defined primary structure. The pilot applications of precise polymeric building blocks have been demonstrated for catalysis and information storage; however, their great potential have not been explored. The PolyProbe scientific goal is to develop a new, highly sensitive and selective method of detection of nonylofenol based on polymers of defined structure in combination with fluorescence spectroscopy.



Sequence programmable polymer materials for the selective sensing of bioactive water pollutants PolySens


The problem of water pollution with bioactive compounds has been growing in the last few years due to the increasing consumption of drugs in developed societies and the pollution of the environment with plastics. Drugs we take are not fully metabolized, are excreted by our body and end up in the natural environment. In particular, very dangerous are endocrine disrupting chemicals (EDCs), as pointed out by the World Health Organization. EDCs can affect the endocrine system and subsequently impair the development and fertility of animals and humans. The aim of the project is to develop a highly sensitive and selective method of detecting bioactive water pollutants based on fluorescent polymers with a defined structure. The monomer sequence of the polymer will be designed to specifically interact with the selected analytes. Programming polymer properties through sequences is a breakthrough approach in the field of polymer materials and allows for very precise modulation of their properties. Polymers defined in their structure can perform functions like natural macromolecules, e.g. receptors, while maintaining appropriate material properties, i.e. stability. In the project, uniform polymers with the designed sequence will be equipped with fluorescent tags and used as probes for the detection of bioactive water pollutants. The result of the project will be the development of a prototype tool for the determination of bioactive water pollutants based on innovative polymer materials. Providing tools for efficient control of the level of bioactive pollutants in water will allow for the widespread introduction of water quality monitoring programs. Wastewater treatment plants will be the direct recipients of the project results, and indirectly the whole community.

Project No. LIDER/27/0148/L-12/20/NCBR/2021.

Sequence-defined macromolecules of controlled folding ConFold

The natural, uniform macromolecules such as proteins and DNA of sequence-defined structures have been inspiring polymer chemists for years. The roles and functions that they can attain are determined by their three-dimensional arrangement that depends on monomer sequence. To reach for the diverse structures and complex properties, represented by native biological polymers, sequence programmability of the synthetic polymer and control of their 3D structure are required.

ConFold aims to investigate structural properties of sequence-defined synthetic polymers -polycarbamates. The general objective in this project is to gain control over the three-dimensional structure of polymers by monomer sequence evolution, as it is observed for natural proteins formed from sequences of amino acids.

ConFold will add a fundamental knowledge of synthesis and structural properties of synthetic sequence-defined polymers to fill a part of the large information gap concerning properties and displayed functions between synthetic polymers and native biological materials. This understanding of sequence-structure relationships will enable to gain better control over polymers properties and will advance their application scope.


Project No 2018/31/D/ST5/01365 funded by Polish National Science Centre

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