Sequence-defined macromolecules of controlled folding
The natural, uniform macromolecules such as proteins and DNA of sequence-defined structures have been inspiring polymer chemists for years. The roles and functions that they can attain are determined by their three-dimensional arrangement that depends on monomer sequence. To reach for the diverse structures and complex properties, represented by native biological polymers, sequence programmability of the synthetic polymer and control of their 3D structure are required.
ConFOLD will add a fundamental knowledge of synthesis and structural properties of synthetic sequence-defined polymers to fill a part of the large information gap concerning properties and displayed functions between synthetic polymers and native biological materials.. This understanding of sequence-structure relationships will enable to gain better control over polymers properties and will advance their application scope.